5 edition of The Hematopoietic Microenvironment found in the catalog.
February 1, 1993
by The Johns Hopkins University Press
Written in English
|Contributions||Michael W. Long (Editor), Max S. Wicha (Editor)|
|The Physical Object|
|Number of Pages||320|
It is well established that the niche, the specific microenvironment surrounding stem cells, plays a vital role in the regulation of stem cell activity. The concept of the stem cell niche was first proposed for the human hematopoietic system (Schofield, ). Buy Handbook of the Hemopoietic Microenvironment (Contemporary Biomedicine 9): Read Kindle Store Reviews -
Studies of the Abnormal Hemopoietic Microenvironment of Sl/Sld Mice.- Summary.- References.- Bone Marrow Microenvironment Clinical Observations.- Clinical Implications.- Functional Abnormalities of Cellular Components of Bone Marrow Microenvironment.- T-Lymphocytes.- Bone Marrow Macrophages.- Bone Marrow Fibroblasts.- References. Series Title. The PP of CFU‐S was evaluated by examining the development of daughter CFU‐S. It was found that, in the hemopoietic microenvironment of induced ossicles, skeletal bone and ectopic ossicles developed by viable osteogenic cells, the PP of CFU‐S is maintained to the same extent.
The physiological basis of this blunted hematopoietic response is unclear, and has been ascribed to age-related deficits in marrow progenitor cell numbers, changes in the marrow microenvironment. Purchase Hematopoietic Stem Cell Niche, Volume 1 - 1st Edition. Print Book & E-Book. ISBN ,
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This book teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Revealing essential roles of the tumor microenvironment in cancer progression, focuses on hematopoietic cells and components of the tumor microenvironment.
Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and.
The hematopoietic microenvironment of the bone marrow: An ultrastructural study of the stroma in rats † Leon Weiss Department of Animal Biology, The University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania Cited by: Critical Reviews in Oncology/Hematology, ; Elsevier Science Publishers B.V.
/91/$ 65 ONCHEM The hematopoietic microenvironment Joel S. Greenberger Department of Radiation Oncolopt, University Cited by: Bone marrow is a semi-solid tissue found within the spongy or cancellous portions The Hematopoietic Microenvironment book bones.
In birds and mammals, bone marrow is the primary site of new blood cell production or haematopoiesis. It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal adult humans, bone marrow is primarily located in the ribs, vertebrae, sternum, and bones of the pelvis.
The bone marrow hematopoietic microenvironment is impaired in iron‐overloaded mice. Hiroshi Okabe. Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Search for more papers by this. This study identifies monocytes as a potential targetable component of the leukemic immune microenvironment. Introduction. B cell progenitor acute lymphoblastic leukemia (B-ALL) is a clonal hematopoietic neoplasm characterized by the proliferation and accumulation of B-lymphoid progenitor cells throughout the bone marrow.
Hematology Comments Off on Tumor Microenvironment: Hematopoietic Cells – Part A. Mar 07 Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment.
Further, it teaches readers about the roles of distinct constituents of the tumor. Normal hematopoiesis is a well-regulated process in which the generation of mature blood elements occurs from a primitive pluripotent stem cell in an ordered sequence of maturation and proliferation.
Regulation occurs at the level of the structured microenvironment. Hematopoietic stem cell differentiation occurs in direct proximity to osteoblasts within the bone marrow cavity. Despite this striking affiliation, surprisingly little is known about the precise cellular and molecular impact of osteoblasts on the bone marrow microenvironment.
The data presented here posit that the young hematopoietic niche contributes to the hybrid B-lymphoid/myeloid differentiation characteristic of human infant B-ALL and suggest that modulation of factors that mediate crosstalk between LICs and the hematopoietic microenvironment, such as Ccl5/Ccr5, may provide a novel therapeutic approach to.
Hematopoietic inductive microenvironments and the hematopoietic stem cell niche: a historical perspective. Blood cell production (hematopoiesis) is a dynamic process that requires the replenishment of more than 7 × 10 9 blood cells (leukocytes, erythrocytes and platelets) per kg body weight per day.
Homeostasis of the hematopoietic system is considered to occur by the capacity of. The Hematopoietic Microenvironment: The Functional and Structural Basis of Blood Cell Development [The Johns Hopkins Series in Hematology/Oncology] (1st Edition) by Michael W.
Long (Editor), Max S. Wicha (Foreword) Hardcover, Pages, Published ISBN / ISBN / Sophisticated cloning techniques now make it possible for. Tumor Microenvironment: Hematopoietic Cells – Part A (1st ed. ) (Advances in Experimental Medicine and Biology #) View larger image.
By: Alexander Birbrair. Synopsis Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. The complex interaction between hematopoietic stem cells (HSCs) and their microenvironment in the human bone marrow ensures a life-long blood production by balancing stem cell maintenance and differentiation.
This so-called HSC niche can be disturbed by malignant diseases. Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor r, it teaches readers about the ro. They are a crucial component of the BM microenvironment that regulates hematopoiesis, through mechanisms largely unknown.
Previously considered as negative regulators of hematopoietic stem cell function, recent data demonstrate their positive support for hematopoietic stem cells depending on the experimental approach.
This indicates that excess iron disturbs the function of the bone marrow microenvironment and delays hematopoietic reconstitution. Microarray and quantitative RT-PCR analysis of non-hematopoietic bone marrow cells (CD/Ter) from the iron-overloaded mice demonstrated significant reductions in CXCL12, VCAM-1, Kit-ligand and IGF-1, which are.
Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor r, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development.
Hematopoiesis is the main function of bone marrow. Human hematopoietic stem and progenitor cells reside in the bone marrow microenvironment, making it a hotspot for the development of hematopoietic diseases. Numerous alterations that correspond to disease progression have been identified in the bone marrow stem cell niche.
Complex interactions between the bone marrow microenvironment. Adult bone marrow contains numerous adipocytes, whose numbers correlate inversely with the haematopoietic activity. Disorders of excess haematopoiesis, such .understand the components of the hematopoietic stem cell (HSC) microenvironment and their important regulative roles.
During the s and s, studies assessing the adult bone marrow (BM) niche were based predominantly on either immunohistochemistry or in vitro stromal culture systems. In these studies, BM stromal cells were deﬁned.This suggests that stromal cells that can support primitive stem cells are rare in the hematopoietic microenvironment.
Taken together, these data substantiate the hypothesis that distinct stromal cells interact selectively with stem cells. This content is only available as a PDF.